2 edition of Glomerular and postglomerular capillary permselectivity in the dog kidney. found in the catalog.
Glomerular and postglomerular capillary permselectivity in the dog kidney.
Catherine I. Whiteside
Written in English
|The Physical Object|
|Number of Pages||102|
Anesthetized mongrel dogs (n = 20) during mannitol diuresis received a pulse of extracellular indicators including I-albumin (plasma reference), [14C]inulin (glomerular reference), creatinine (interstitial reference), and a neutral [3H]dextran (specific mol wt betw dalton) in . The objective of the present study was to evaluate the relative roles of pre- and postglomerular vascular resistance changes in the autoregulation phenomenon. Experiments were performed on isolated dog kidneys perfused during ureteral occlusion. Ureteral pressures were assumed to approximate Bowman capsule extravascular pressure.
Pre- and post-glomerular vascular resistances can only be quantified by the direct measurement of glomerular capillary pressure and this can only be achieved using the demanding technique of renal micropuncture. Kate’s laboratory is unique in Australia and only one of a handful in the world to have established these techniques. Regulation of Glomerular Capillary Pressure and Filtration Rate in Young Kyoto Hypertensive Rats Article (PDF Available) in Clinical Science 56(3) April with 95 Reads.
chronic kidney disease (CKD) in dogs and cats occurred late in the course of disease, usually aft er Ang II modulates glomerular barrier permselectivity by promoting glomerular capillary hypertension thus exposing post-glomerular tubular segments to hypoxia.2 As described above. Permselectivity of the glomerular capillary wall. Facilitated filtration of circulating polycations. J Clin Invest 72–78, Crossref | PubMed | ISI Google Scholar; 7 Bolton GR, Deen WM, and Daniels BS. Assessment of the charge selectivity of glomerular basement membrane using Ficoll sulfate. Am J Physiol Renal Physiol F–F
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Abstract. To determine the permselectivity characteristics of the glomerular capillary wall, known molecular size fractions of [3H]dextran, prepared by gel chromatography, were infused into normally hydrated Wistar rats, thus permitting simultaneous measurement of Bowman's space/plasma water (BS/P) and urine/plasma water (U/P) concentration ratios, along with glomerular pressures and by: Quantitative importance of changes in postglomerular colloid osmotic pressure in mediating glomerulotubular balance in the rat.
J Clin Invest. Jan; 52 (1)– [PMC free article] Bennett CM, Glassock RJ, Chang RL, Deen WM, Robertson CR, Brenner BM, Troy JL, ueki IR, Rasmussen B.
Permselectivity of the glomerular capillary by: Abstract. To examine the electrostatic effects of fixed negative charges on the glomerular capillary wall, polydisperse [3 H]DEAE dextran, a polycationic form of dextran, was infused into 10 Munich-Wistar onal clearances of DEAE ranging in radius from 18 to 44Å were determined in these rats, together with direct measurements of the forces and flows governing the glomerular Cited by: Glomerular and postglomerular permselectivity to anionic dextrans in the dog.
Whiteside C, Silverman M. Glomerular (G) and postglomerular (PG) capillary permselectivity to anionic dextran markers was investigated using the multiple-indicator-dilution (MID) technique in anesthetized mongrel dogs Cited by: 7.
The glomerulus (plural glomeruli), is a network of small blood vessels (capillaries) known as a tuft, located at the beginning of a nephron in the tuft is structurally supported by the mesangium - the space between the blood vessels - made up of intraglomerular mesangial blood is filtered across the capillary walls of this tuft through the glomerular filtration barrier Location: Nephron of kidney.
Jürgen B. Schnermann, Josephine P. Briggs, in Seldin and Giebisch's The Kidney (Fourth Edition), Stop-flow Pressure. Measurement of stop-flow pressure (P SF) in single nephrons was introduced as a method to estimate glomerular capillary pressure (P GC) in nephrons that do not possess superficial glomeruli ().P SF can be measured reliably over extended periods of time, and it has.
Laboratory Investigation Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions Ramsay L.S.
Chang, William M. Deen, Channing R. Robertson, Barry M. Brenner, Dr Barry M Brenner 1 Kidney Research Laboratory, Veterans Administration Hospital, San Francisco; the Departments of Medicine and Physiology and the Cardiovascular Research Institute of the University.
Glomerular and postglomerular transcapillary exchange in dog kidney. (PMID) Abstract was used to study glomerular and postglomerular permselectivity to neutral dextran molecular weight markers in anesthetized dogs undergoing mannitol diuresis.
Application of a barrier-limited distributed model permitted quantitation of. The glomerular barrier is the kidney’s physical block to the unrestricted flow of molecules from the plasma into the urinary space. Its exquisite selectivity allows solutes and water in the glomerular capillaries to pass through but it prevents the bulk of.
The permselectivity characteristics of the postglomerular (PG) microcirculation in dog kidney were investigated employing 3H-labeled cationic (DEAE) and anionic sulfated dextrans (dextran-SO4) ranging from 19 to 29 A Stokes-Einstein Radius.
Glomerular permselectivity is dependent on adequate serum concentrations of orosomucoid. Orosomucoid, or α 1-acid glycoprotein, a serum protein known to be an “acute phase reactant” has recently been shown to be needed for the maintenance of normal capillary permeability in skeletal muscle and ore, we were interested in studying whether the glomerular capillary.
Chang RLS, Deen WM, Robertson CR, et al: Permselectivity of the glomerular capillary wall. III. Restricted transport of polyanions. Kidney Int 8: –, PubMed CrossRef Google Scholar 3. Postglomerular capillary solute flux restricted by shape and charge in the dog. Whiteside C, Silverman M. The permselectivity characteristics of the postglomerular (PG) microcirculation in dog kidney were investigated employing 3H-labeled cationic (DEAE) and anionic sulfated dextrans (dextran-SO4) ranging from 19 to 29 A Stokes-Einstein Radius.
For example, one study showed that in adults 2% of glomerular endothelial cells have diaphragmed fenestrae and caveolae. 33 Diaphragmed fenestrae ( nm in diameter) were more uniform in shape and size than nondiaphragmed ones ( nm in largest diameter).
33 In the same report, % of capillaries stained for PV 33 As another example. Ueki, and T. Daugharty. On estimating colloid osmotic pressure in pre- and postglomerular plasma in the rat.
Kidney J. Strandhoy, and E. Schneider. Hydrostatic pressures in proximal tubules and peritubule capillaries in the dog. Kidney Int. 2: 11 Permselectivity of the glomerular capillary wall to macromolecules.
from book Understanding Kidney Diseases (pp) Kidney Anatomy and Physiology. tufts and the early part of the post-glomerular capillaries in the cortex and outer medulla (Courtesy.
The renal disposition characteristics of In-labeled neocarzinostatin (NCS), soybean trypsin inhibitor (STI), and superoxide dismutase (SOD) were studied in the perfused rat kidney. In a single-pass indicator dilution experiment, venous and urinary recovery profiles and tissue accumulation of proteins were determined under filtering or nonfiltering conditions.
C Whiteside's 22 research works with citations and 2, reads, including: BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis. With effectively a molecular radius of 36Å in relation to the glomerular capillary wall, and sieving coefficient of approximatelythe flux of albumin through the permselectivity barrier of.
Glomerular Capillary Oncotic Pressure Peritubular Capillary Efferent Arteriole Glomerular Capillary Wall These keywords were added by machine and not by the authors.
This process is experimental and the keywords may be updated as the learning algorithm improves. Of interest, restoring kidney perfusion relieves postglomerular vasoconstriction, which leads to a decrease of filtration fraction to normal ranges 10 x 10 Chang, R.L.S., Deen, W.M., Robertson, C.R.
et al. Permselectivity of the glomerular capillary wall: Studies of experimental glomerulonephritis in the rat using neutral dextran. J Clin Invest.Plasma albumin restricts capillary water filtration.
Accordingly, the glomerular ultrafiltration coefficient is higher in Nagase analbuminemic rats (NAR) than in Sprague-Dawley controls. We investi.The renal glomerulus contains at least three cell types: endothelial cells, glomerular epithelial cells (GEC), and mesangial cells.
The endothelial cell which lines the glomerular capillary wall is characterized by the presence of fenestrae approximately Å in diameter. The role that these cells play in glomerular function is not clear.